Detalhe da pesquisa
1.
Early prediction of clinical response to anti-TNF treatment using multi-omics and machine learning in rheumatoid arthritis.
Rheumatology (Oxford)
; 61(4): 1680-1689, 2022 04 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34175943
2.
Distinct clinical phenotypes for Crohn's disease derived from patient surveys.
BMC Gastroenterol
; 21(1): 160, 2021 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33836648
3.
Standard machine learning approaches outperform deep representation learning on phenotype prediction from transcriptomics data.
BMC Bioinformatics
; 21(1): 119, 2020 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32197580
4.
A probabilistic pathway score (PROPS) for classification with applications to inflammatory bowel disease.
Bioinformatics
; 34(6): 985-993, 2018 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29048458
5.
Public Domain HTS Fingerprints: Design and Evaluation of Compound Bioactivity Profiles from PubChem's Bioassay Repository.
J Chem Inf Model
; 56(2): 390-8, 2016 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26898267
6.
Using mutagenesis and structural biology to map the binding site for the Plasmodium falciparum merozoite protein PfRh4 on the human immune adherence receptor.
J Biol Chem
; 289(1): 450-63, 2014 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-24214979
7.
Experimental design strategy: weak reinforcement leads to increased hit rates and enhanced chemical diversity.
J Chem Inf Model
; 55(5): 956-62, 2015 May 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25915687
8.
Decoding the components of dynamics in three-domain proteins.
J Comput Chem
; 35(7): 518-25, 2014 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24323885
9.
Molecular signature of methotrexate response among rheumatoid arthritis patients.
Front Med (Lausanne)
; 10: 1146353, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37051216
10.
Peripheral blood cellular dynamics of rheumatoid arthritis treatment informs about efficacy of response to disease modifying drugs.
Sci Rep
; 13(1): 10058, 2023 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37344505
11.
Estimation of interdomain flexibility of N-terminus of factor H using residual dipolar couplings.
Biochemistry
; 50(38): 8138-49, 2011 Sep 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-21793561
12.
What Is the Persistence to Methotrexate in Rheumatoid Arthritis, and Does Machine Learning Outperform Hypothesis-Based Approaches to Its Prediction?
ACR Open Rheumatol
; 3(7): 457-463, 2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-34085401
13.
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics.
Sci Rep
; 11(1): 7266, 2021 03 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-33790392
14.
Peptide-TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens.
Nat Biotechnol
; 38(3): 320-332, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31932728
15.
Profiling of Gene Expression Biomarkers as a Classifier of Methotrexate Nonresponse in Patients With Rheumatoid Arthritis.
Arthritis Rheumatol
; 71(5): 678-684, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30615300
16.
Molecular Profiling of Ulcerative Colitis Subjects from the TURANDOT Trial Reveals Novel Pharmacodynamic/Efficacy Biomarkers.
J Crohns Colitis
; 13(6): 702-713, 2019 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30901380
17.
Mendelian Disease Associations Reveal Novel Insights into Inflammatory Bowel Disease.
Inflamm Bowel Dis
; 24(3): 471-481, 2018 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29462399
18.
Reverse translation of adverse event reports paves the way for de-risking preclinical off-targets.
Elife
; 62017 08 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28786378
19.
Implications of Dynamic Occupancy, Binding Kinetics, and Channel Gating Kinetics for hERG Blocker Safety Assessment and Mitigation.
Curr Top Med Chem
; 16(16): 1792-818, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26975508
20.
Diversity selection of compounds based on 'protein affinity fingerprints' improves sampling of bioactive chemical space.
Chem Biol Drug Des
; 82(3): 252-66, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23647865